还没做过化疗，EGFR是野生型的病友一定要去做ALK的检测

jzjqian 发表于 2012-7-25 15:45

                               
登录/注册后可看大图

, A' @5 ?, x2 [* M请教，像我这样的，手术22个月了，还能去原手术医院拿到病理作EGFR检查么？

可以，但要有针对性，

请问，肺鳞癌，只做过一次化疗，骨髓抑制严重，后吃特罗凯4个月基本无效，可以参加实验组吗？

不可以了,要没做过任何治疗的,包括化疗和靶向药

Concomitant EGFR mutation and EML4-ALK gene fusion in non-small cell lung cancer.  Print this page  
  t# ^$ M. |5 o" A9 z+ a

  |  V$ b5 c6 hSub-category:
" R+ b7 U' S$ h- d. b0 fMolecular Targets
; n8 S- L- w+ f. y
, Q7 t7 M" h) \: c' p% a! d* M
0 e3 q( n; R  a: x. A  tCategory:
Tumor Biology
0 K3 @9 ~* ]& R1 B$ E5 y, E
. B; ~8 @, p. g% k# Y& d& z
Meeting:
+ v3 G( H) v8 [: L. E1 I& D2011 ASCO Annual Meeting
" J" `, u6 X$ _
2 G5 O+ N; D4 f; Q1 O6 i# a
Session Type and Session Title:
Poster Discussion Session, Tumor Biology

& b: \8 z$ A; }& o
0 x) I6 E1 t$ W* _: Z, wAbstract No:
10517

) B+ P6 \2 i- j# `! ]4 W. e
% I: W& D1 b7 g' w6 kCitation:
J Clin Oncol 29: 2011 (suppl; abstr 10517)


Author(s):
J. Yang, X. Zhang, J. Su, H. Chen, H. Tian, Y. Huang, C. Xu, Y. L. Wu; Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou, China; Guangdong Lung Cancer Institute, Medical Research Center of Guangdong General Hospital, Guangzhou, China; Guangdong Lung Cancer Institute, Guangzhou, China; Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou, China
0 X/ F: H& O" f8 _- |
& N5 q* Z% R+ c
, C2 e; G( v! g
- B4 C/ r8 w5 X9 l, UAbstracts that were granted an exception in accordance with ASCO's Conflict of Interest Policy are designated with a caret symbol (^) here and in the printed Proceedings.
) Y1 Z) U5 c5 X8 @  ]# Z: X
! I0 @9 W$ n1 T+ `' hAbstract Disclosures

' q. u% W( E: }Abstract:
+ |) F- n6 X# Q
0 G: g9 ?) q$ b5 Y9 D0 D# T" |
Background: The fusion of the anaplastic lymphoma kinase (ALK) with the echinoderm microtubule-associated protein-like 4 (EML4) and epidermal growth factor receptor (EGFR) mutations are considered mutually exclusive. Advanced non-small cell lung cancer (NSCLC) patients with EML4-ALK did not benefit from EGFR tyrosine kinase inhibitors (TKIs). Methods: Multiplex reverse transcriptase-polymerase chain reaction (RT-PCR) followed by sequencing was performed for EML4-ALK fusion status detection. EGFR and KRAS mutations were determined by direct DNA sequencing. Positive results of EML4-ALK fusion were also confirmed by RACE-coupled PCR sequencing. Results: From April 2010 to January 2011, 412 patients (398 with NSCLC; 14 with SCLC) were tested for mutation status of EGFR, KRAS and EML4-ALK respectively. Frequency of EML4-ALK fusion was 10.6% (42/398) in NSCLC patients. No patients with SCLC were found to have positive EML4-ALK fusion. Frequency of concomitant EGFR and EML4-ALK gene mutations was 1.0% (4/398) in NSCLC patients, and their variants of EML4-ALK gene mutations were Variant 1 (3 patients) and Variant 6 (1 patient); being never smokers, all of them were diagnosed with advanced (3 with stage †W and 1 with stage IIIB) adenocarcinoma harbouring wild type KRAS. Two female stage †W patients with double gene mutations (1 with L858R and Variant 1; 1 with exon19 deletion and Variant 6) received first-line gefitinib which is one kind of EGFR TKIs and achieved partial response. Conclusions: Though being rare events, NSCLC patients harbouring concomitant EGFR mutation and EML4-ALK gene fusion are sensitive to first-line EGFR TKIs. Whether they could also benefit from ALK inhibition after failure to EGFR TKIs warranted further investigation.

2 D7 c: z9 S; {% C: H1 K$ s

由吴一龙教授牵头的A80810029临床试验上周启动，初诊未治疗的晚期肺腺癌患者检测到ALK阳性，可参加一线crizotinib 对比力比泰+卡铂的临床研究，药物全部免费，即使分配到力比泰组，疾病进展之后可免费获得crizotinib.

没有手术，只化疗过，现吃靶向药，未突变，alk未测，有机会入组吗？

boeun 发表于 2012-11-18 16:37

, p8 Y/ N- k7 A, N3 R                               
登录/注册后可看大图

没有手术，只化疗过，现吃靶向药，未突变，alk未测，有机会入组吗？

% \/ }  K9 n' j1 m3 b* `化疗过的没机会了

平安！ 发表于 2012-7-20 11:20

) J& t; Y$ Q% R4 }/ g                               
登录/注册后可看大图

易瑞沙、特罗凯有效的病人基本上可以断定ALK（-）。极其罕见EGFR、ALK同时突变的。
3 Q) R" w4 b; o) {$ \0 cALK一个指标医院要900多 ...

, f: e. L$ E. B+ j8 i平安，真的没有希望吗？我弟弟虽然特罗凯有效，但是ＥＧＦＲ是野生型，不是突变啊。有没有必要去检测ＡＬＫ呢？
% `) ^# T$ `9 d# [/ I
* `5 E1 }5 G) x: p现在病情进展，快没招儿了。

好像想加入挺困难的

小地方没条件做啊