还没做过化疗，EGFR是野生型的病友一定要去做ALK的检测

jzjqian 发表于 2012-7-25 15:45

" |3 |8 z: M( B* `' x; @! I                               
登录/注册后可看大图

请教，像我这样的，手术22个月了，还能去原手术医院拿到病理作EGFR检查么？

: J% n2 S4 A. a. e6 @" {, q可以，但要有针对性，

请问，肺鳞癌，只做过一次化疗，骨髓抑制严重，后吃特罗凯4个月基本无效，可以参加实验组吗？

不可以了,要没做过任何治疗的,包括化疗和靶向药

Concomitant EGFR mutation and EML4-ALK gene fusion in non-small cell lung cancer.  Print this page  

* _0 y0 u0 x) D% O
Sub-category:
4 J* q6 L# L% @9 j8 ~1 ]/ ~Molecular Targets
; O- B5 D# i- Z
) R3 o2 _' m1 w* P9 T9 S3 v
. R& g) u' D9 l7 W* T' ^6 KCategory:
( C/ ^6 O. M% W; w, FTumor Biology


Meeting:
1 t) m% I4 l( B2011 ASCO Annual Meeting

2 M9 t  r- a& y) t+ r# E
Session Type and Session Title:
% A5 s0 Y' s, xPoster Discussion Session, Tumor Biology

! z* g5 B9 \5 q# M7 W% l
Abstract No:
5 g6 r* H6 r& R- v10517
) ?) _+ B% X" b: i! c
9 h0 J/ K3 t, d/ g9 G0 Y
5 v. t, x, a; DCitation:
J Clin Oncol 29: 2011 (suppl; abstr 10517)
, e, v* |, M: o2 R

. k% M& e0 R, P8 E+ B1 s- yAuthor(s):
J. Yang, X. Zhang, J. Su, H. Chen, H. Tian, Y. Huang, C. Xu, Y. L. Wu; Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou, China; Guangdong Lung Cancer Institute, Medical Research Center of Guangdong General Hospital, Guangzhou, China; Guangdong Lung Cancer Institute, Guangzhou, China; Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou, China
: G7 P% B3 n4 i0 p( u& K


2 e  Z: Q) O% y. ?8 N8 @# F( ~Abstracts that were granted an exception in accordance with ASCO's Conflict of Interest Policy are designated with a caret symbol (^) here and in the printed Proceedings.

Abstract Disclosures
' G7 o' B9 ~0 d5 d8 w/ w5 |) B
, m% b* @, F8 ?# g: Q5 _Abstract:
: E: b6 P; j* q8 F- v' [9 Q

/ o% q! d9 _& u5 iBackground: The fusion of the anaplastic lymphoma kinase (ALK) with the echinoderm microtubule-associated protein-like 4 (EML4) and epidermal growth factor receptor (EGFR) mutations are considered mutually exclusive. Advanced non-small cell lung cancer (NSCLC) patients with EML4-ALK did not benefit from EGFR tyrosine kinase inhibitors (TKIs). Methods: Multiplex reverse transcriptase-polymerase chain reaction (RT-PCR) followed by sequencing was performed for EML4-ALK fusion status detection. EGFR and KRAS mutations were determined by direct DNA sequencing. Positive results of EML4-ALK fusion were also confirmed by RACE-coupled PCR sequencing. Results: From April 2010 to January 2011, 412 patients (398 with NSCLC; 14 with SCLC) were tested for mutation status of EGFR, KRAS and EML4-ALK respectively. Frequency of EML4-ALK fusion was 10.6% (42/398) in NSCLC patients. No patients with SCLC were found to have positive EML4-ALK fusion. Frequency of concomitant EGFR and EML4-ALK gene mutations was 1.0% (4/398) in NSCLC patients, and their variants of EML4-ALK gene mutations were Variant 1 (3 patients) and Variant 6 (1 patient); being never smokers, all of them were diagnosed with advanced (3 with stage †W and 1 with stage IIIB) adenocarcinoma harbouring wild type KRAS. Two female stage †W patients with double gene mutations (1 with L858R and Variant 1; 1 with exon19 deletion and Variant 6) received first-line gefitinib which is one kind of EGFR TKIs and achieved partial response. Conclusions: Though being rare events, NSCLC patients harbouring concomitant EGFR mutation and EML4-ALK gene fusion are sensitive to first-line EGFR TKIs. Whether they could also benefit from ALK inhibition after failure to EGFR TKIs warranted further investigation.

/ I7 Z. l( q% c
% R% w, ]9 Y1 {! P% g! m. Q

由吴一龙教授牵头的A80810029临床试验上周启动，初诊未治疗的晚期肺腺癌患者检测到ALK阳性，可参加一线crizotinib 对比力比泰+卡铂的临床研究，药物全部免费，即使分配到力比泰组，疾病进展之后可免费获得crizotinib.

没有手术，只化疗过，现吃靶向药，未突变，alk未测，有机会入组吗？

boeun 发表于 2012-11-18 16:37

" p2 S& Z5 i+ c# S& x+ O6 Q! O/ e                               
登录/注册后可看大图

没有手术，只化疗过，现吃靶向药，未突变，alk未测，有机会入组吗？

; y1 n% H( ?7 d. ^' C化疗过的没机会了

平安！ 发表于 2012-7-20 11:20

: p3 B  i$ l- v. M% k                               
登录/注册后可看大图

易瑞沙、特罗凯有效的病人基本上可以断定ALK（-）。极其罕见EGFR、ALK同时突变的。
7 a( |  W5 s% G8 d" vALK一个指标医院要900多 ...

  O* e/ I& [2 `: Q. x0 E; t- y2 r" K平安，真的没有希望吗？我弟弟虽然特罗凯有效，但是ＥＧＦＲ是野生型，不是突变啊。有没有必要去检测ＡＬＫ呢？
9 e. d/ g! z% N: Z4 L* l+ Q" l
$ ]" T) P/ |. u9 x现在病情进展，快没招儿了。

好像想加入挺困难的

小地方没条件做啊