脑部放疗，上午比下午敏感许多！
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Cancer 2011 Jan 15;117(2):414-20. doi: 10.1002/cncr.25423. Epub 2010 Sep 9.
) ?2 A( \% k2 ?- ]0 k+ HGamma knife radiosurgery for brain metastasis of nonsmall cell lung cancer: is there a difference in outcome between morning and afternoon treatment?
0 Z/ C, f) p- a5 X: gRahn DA 3rd, Ray DK, Schlesinger DJ, Steiner L, Sheehan JP, O'Quigley JM, Rich T.
( H4 N, J2 `( G& l$ @" x, _SourceDepartment of Radiation Oncology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA.% S& o$ I0 Z. M* c- n* `
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Abstract
2 J' r1 X. Z8 h* LBACKGROUND: Circadian cell-cycle progression causes fluctuating radiosensitivity in many tissues, which could affect clinical outcomes. The purpose of this study was to determine whether outcomes of single-session gamma knife radiosurgery (GKRS) for metastatic nonsmall cell lung cancer (NSCLC) differ based on treatment time. U& N$ ?( u. k5 H' k7 ~1 ^1 h
' }. b6 K8 ?$ E- O4 GMETHODS: Fifty-eight patients received GKRS between 10:00 am and 12:30 pm and 39 patients received GKRS between 12:30 pm and 3:00 pm. The mean peripheral dose was 18.6 Gy. The mean tumor size was 7.3 cm³. Magnetic resonance imaging was used to score local control at 3 months. Cause of death (COD) was categorized as central nervous system (CNS)-related or systemic.
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2 _% m( \! m0 D3 w4 y. TRESULTS: Demographic and disease characteristics of the 2 groups were similar. Local control at 3 months was achieved in 97% (35/36) of patients who underwent GKRS early in the day versus 67% (8/12) of patients who underwent GKRS later in the day (chi-square, P = .014). Early GKRS was associated with better survival (median 9.5 months) than late GKRS (median 5 months) (Kaplan-Meier log-rank test, P = .025). Factors contributing to better survival in a Cox regression model included early treatment time (P = .004) and recursive partition analysis class (P < .001). Cause of death in the early treatment group was CNS-related in 6% (3/47) of patients versus 24% (8/34) of patients in the late treatment group (chi-square test, P = .026).
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CONCLUSIONS: GKRS for metastatic NSCLC had better local control, better survival, and a lower rate of CNS-related cause of death when given earlier in the day versus later in the day. These retrospective data should encourage future study in brain radiosurgery and non-CNS stereotactic body radiotherapy series.5 V1 A4 M; ]5 F a4 ?' T
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惋惜 关于一位术后2期肺腺癌病友止步
曾经一起抗癌的老病友很多都陆陆续续地抗癌结束了，如今都各自有了新的生活，当
晚期肺癌跨越7年，我的血泪教训提醒
讲述者：飘飘整理者：pear
2013年我确诊宫颈癌，万幸发现及时得以手术根治。祸不单行
收官巨献！吴一龙教授详解肺癌“兵器
作者：雨过天晴每年11月的“国际肺癌关注月”，都是凝聚抗癌力量、普及科学认知的重要
无进展生存期超25个月！奥希替尼+局
作者：seacat
既往研究提示通过对寡转移病灶进行手术或放疗（局部巩固治疗LCT），可改
不知不觉进入第七年。。胸腔积液怎么
中间这几年很顺利也很稳定 这几年都没再关注这个平台。空窗一年半，最近一次复查胸腔
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显身卡
