发给老马备查:# V( F' Q2 t. K+ i! @/ X6 W4 Y4 \
滴水察海(69304838) 15:23:23$ R/ |$ n `# y( Q5 G! Q3 s' H+ l
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱 M% r) m+ G* Q: t( o
吉非替尼和S-1连用的依据; T8 |, e3 {& ~# d. P$ y% k% s
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
! I5 E1 Q( @/ l8 x8 [% h) i, C0 q0 w是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
: p1 @& ]4 u, i这样是不是推理出,耐药后,可以用S-1和培美了?, v. `1 a4 G& S9 m& U
结论:
7 r5 ?# V& Q) H7 J# R, N V) M, _如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |