发给老马备查:. g- ?2 p& ~; U3 i1 T5 c t! F8 I
滴水察海(69304838) 15:23:23& t6 d3 K+ t) R/ q0 u% `
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱1 `: q, P6 Y* A3 E& j
吉非替尼和S-1连用的依据8 d% W4 _; O, d* U
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
3 |: _ {- x. u. V4 Z% q; B1 [/ t$ v是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达8 y2 v1 o+ V) V: k! y
这样是不是推理出,耐药后,可以用S-1和培美了?
( M- A/ Y. ], o; J6 \结论:
$ j6 w6 i5 p; C如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |